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Antibody fragmentation
Generating fragments from an existing antibody are commonly created by enzymatic cleavage or chemical reduction but fragments can also be generated recombinantly.
Using antibody fragments offers several advantages over full-length antibodies. Their smaller size improves tissue penetration, while the absence of the Fc region reduces non-specific binding and eliminates effector functions.
Depending on the cleavage site different fragments are obtained:
- Above hinge region: Produces two Fab fragments
- Below hinge region: Produces one F(ab’)2 fragment
Below is an overview of the antibody fragments.
Contact us for a free consultation on generating the fragments you need.